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Updated16 mai 2018
The concept, measurement, and integration of response shift phenomenon in Patient-Reported Outcomes data analyses - On certain methodological and statistical considerations
Vanier Antoine - Post-Doctoral Researcher in Biostatistics - University of Nantes
Patient-Reported Outcomes are increasingly used in health-related research. These instruments allow the assessment of subjective concepts such as Health-Related Quality of Life, anxiety level, pain or fatigue. Initially, the interpretation of a difference in score over time was based on the assumption that the meaning of concepts and measurement scales remains stable in individuals’ minds over time. This assumption has been challenged. Indeed, the self-assessment of a concept is now understood as a contingency of the subjective meaning a subject has of this concept, which can change over time especially as a result of a salient medical event: the “response shift” phenomenon. Since the end of the 1990s, researches on response shift phenomenon has become of prime interest in the field of health-related research. If developments have been made, it is still a young field with various scientific debates on a theoretical, methodological and statistical level. Thus, the broad objective of this thesis is to investigate some methodological and statistical issues regarding response shift concept, detection and integration into PRO data analyses. The manuscript is composed of three main works: a state of the art and synthesis of the works conducted at an international level since response shift phenomenon is investigated, a pilot study investigating the statistical performances of the Oort’s Procedure (a popular method of response shift detection using Structural Equation Modeling) by simulations and a theoretical work about the links between response shift occurrence and semantic complexity of concepts measured and items used.
Vanier A, Falissard B, Sébille V, Hardouin JB(2017) The complexity of interpreting changes observed over time in Health-Related Quality of Life: a short overview of 15 years of research on response shift theory. In Guillemin F, Leplège A, Briançon S, Spitz E, Coste J. Perceived health and adaptation in chronic disease. Stakes and future challenge (Taylor and Francis): 202-230. Vanier A(2016) Thèse de science biostatistique - Université de Nantes. The concept, measurement and integration of response shift phenomenon in Patient-Reported Outcomes data analyses. On certain methodological and statistical considerations. , 174 pages.
Vanier A, Sébille V, Blanchin M, Guilleux A, Hardouin JB(2015) Overall performance of Oort's procedure for response shift detection at item-level: a pilot simulation study. Quality of life research, 24(8): 1799-807.
Vanier A, Leplège A, Hardouin JB, Sébille V, Falissard B(2015) Semantic primes theory may be helpful in designing questionnaires such as to prevent response shift. Journal of Clinical Epidemiology, 68(6): 646-654.
Blanchin M. , Guilleux A. , Vanier A. , Hardouin J.B. , Sébille V. Comparison of Item Response Theory and Structural Equation Models for response shift detection at the item level.21th annual conference of ISOQOL, 15-18 october 2014, Berlin, Germany, 2014. Vanier A. , Sébille V. , Blanchin M. , Guilleux A. , Hardouin J.B. Power and Type-I-Error of global assessment of response shift occurrence using Likelihood-Ratio Test or information criteria in Oort’s procedure: a simulation study.21th annual conference of ISOQOL, 15-18 october 2014, Berlin, Germany, 2014. Vanier A. , Leplège A. , Hardouin J.B. , Sébille V. , Falissard B. Semantic primes: a possible way to avoid Response Shift?.21th annual conference of ISOQOL, 15-18 october 2014, Berlin, Germany, 2014. Guilleux A. , Blanchin M. , Vanier A. , Hardouin J.B. , Sébille V. Searching for an optimal SEM-based method for response shift detection in longitudinal patient-reported outcomes studies – A simulation study.21th annual conference of ISOQOL, 15-18 october 2014, Berlin, Germany, 2014. Vanier A. , Leplège A. , Hardouin J.B. , Sébille V. , Falissard B. Semantic primes, une possibilité pour éviter le Response Shift ?.Chronic diseases, adaptation and perceived health: stakes and future - Young Researchers Days, 3-6 juin 2014, Nancy, 2014.
Début : Octobre 2013
Fin : Octobre 2016