UMR INSERM 1246 - SPHERE
MethodS in Patients-centered outcomes
and HEalth ResEarch

INSERM Univ Nantes Univ Tours
EA4275-SPHERE
  • Home
  • Team
  • Organigram
  • Links
  • Legal
  • Contact

Research

Topics Publications In progress publications Communications

Packages

AnaQol Project PRO-online R Packages Online R-package

Life of the unit

Projects Collaborations PhD thesis Traineeships Traineeships propositions Seminars

Next seminars

Last publications

02 septembre 2020 Devos G, Clark L, Bowden-Jones H, Grall-Bronnec M, Challet G, Khazaal Y, Maurage P, Billieux J (2020) The joint role of impulsivity and distorted cognitions in recreational and problem gambling: A cluster analytic approach. Journal of Affective Disorders(127): 473-482.

19 novembre 2019 Enjalbert L, Hardouin JB, Blanchin M, Giral M, Morelon E, Cassuto E, Meurette A, Sébille V (2019) Comparison of longitudinal quality of life outcomes in preemptive and dialyzed patients on waiting list for kidney transplantation. Quality of Life Research: .

30 octobre 2019 Blanchin M, Guilleux A, Hardouin JB, Sébille V (2019) Comparison of SEM, IRT and RMT-based methods for response shift detection at item level: a simulation study. Statistical Methods in Medical Research: .

02 octobre 2019 Lascarrou J, Merdji H, Le Gouge A, Colin G, Grillet G, Girardie P, Coupez E, Dequin PF, Cariou A, Boulain T, Brule N, Frat JP, Asfar P, Landais M, Plantefeve G, Quenot J, Chakarian J, Sirodot M, Legriel S, Letheulle J, Thevenin D, Desachy A, Delahaye A, Botoc V, Vimeux S, Martino F, Giraudeau B, Reignier J, CRICS-TIGGERSEP Group (2019) Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm. N Engl J Med: doi: 10.1056/NEJMoa1906661. [Epub ahead of print].

01 octobre 2019 Bourdon M, Blanchin M, Campone M, Quéreux G, Dravet F, Sébille V, Bonnaud-Antignac A (2019) A comparison of post-traumatic growth changes in breast cancer and melanoma. Health psychology, 38(10): 878-887.

Updated

11 décembre 2019

Scientific project of the INSERM Unit U1246 SPHERE

welcome xhdzyPsychological, cultural, behavioural, environmental and economic factors are recognized as potentially influencing the health and patients’ outcomes. However, in epidemiology and clinical research, addressing these "unique individual circumstances" remains a challenge. Researchers, physicians and policy-makers are indeed often faced with problems in measuring and interpreting patients' experiences, their adaptation to the disease, their relationships with their environment, their preferences and feelings, and the impact that the perception of their disease can have on their prognosis.

The unit SPHERE aims to promote patient-centred methodological research and to reinforce the contribution of patients-reported data (quality of life, fatigue, well-being…) in decision-making and assessment of care. Our scientific project takes place within three interacting axes developed in an interdisciplinary perspective: 1) measurement and interpretation of patients' perception and experience, 2) real-life evaluation taking into account the patient's environment, and 3) patient-centred stratified medicine. The objectives of the 3 axes are to propose adapted methodologies to better evaluate and understand patients’ adaptation to their disease and to provide improved interpretation of patients-reported outcomes, to take into account the environment of the patient in the pragmatic evaluation of patient’s management and prognosis, to integrate patients’ perspectives and preferences into medical decision making and prognostic evaluation.


Le LabCom RISCA

LabCom RISCALe laboratoire SPHERE et la société IDBC (groupe A2com) ont décidé de créer ensemble le Laboratoire Commun RISCA (Research in Informatics and Statistics for Cohort-based Analyses). Ce LabCom est financé par l'ANR pour 5 ans (2017-2021).

New PhD and Master students

  • Yseulys Dubuy : Définition et validation d’une méthode de détection du Response-Shift au niveau individuel à l’aide des erreurs de Guttman (2019)
  • Arthur Chatton : Inférence causale à partir de données observationnelles et censurées : l’intelligence artificielle au service du biostatisticien, épidémiologiste et clinicien (2019-2022)
  • Marion Kerioui : Estimation des paramètres d’un modèle conjoint de données longitudinales non-linéaires et de survie par une méthode bayésienne (2018)
  • Julie Paul : Etude des données de qualité de vie de l'essai clinique CORTI-TC (Traitement de l'insuffisance surrénale secondaire à un traumatisme crânien grave) (2018)
  • Maxime Guettier : Facteurs prédictifs d'échec de traitement d'une infection sur prothèse (2018)

level-1 Master’s degree in “Bioinformatics – Biostatistics”

welcome xhdzyIn 2012, a new level-1 Master’s degree in “Bioinformatics – Biostatistics” has been created. This Master offers the opportunity to pursue in two different level-2 Masters’ degrees: 1) “Modeling in Clinical Pharmacology and Epidemiology or 2) “Bioinformatics”

For more details, clic here, and you can contact Jean-Benoit Hardouin (referent for Biostatistiqcs), or Christine Sinoquet (referent for Bioinformatics).



UMR INSERM 1246 - SPHERE MethodS for Patients-centered outcomes and Health ResEarches | Webmaster